Formulation and Design of Multiunit Particulate System (MUPS) Tablet of Pantoprazole by QbD: Effect of Compression Variables on the Finished Product.

The aim of the study was to optimize compression process variables of Pantoprazole oro-dispersible (Multiunit particulate system) MUPS tablet. Enteric coated Pantoprazole pellets were compressed to oro-dispersible tablet for geriatric and pediatric patients for easy administration. The risk related to compression process variables was identify, assessed and mitigated using Failure Mode and Effect Analysis (FMEA). A full factorial design was applied to develop design space and determine control strategy for compression process, which were developed, have promising chemical and physical results. The compression process variables studied were pre-compression force (X1), main compression force (X2) and turret speed (X3), versus affecting hardness (Y1), disintegration time (Y2), friability (Y3), weight variation (Y4), content uniformity (Y5), drug release in 0.1N HCl (Y6) and assay (Y7) as responses/Critical quality attributes (CQAs). Response surface graphs depicted that X2 had more impact on CQAs than X1. Design space plot revealed that tablet CQAs were within limit when X3 maximum 44 rpm and X2 in the range of 10 to 12.5 kN. Scale up performed on commercial scale compression machine of same make that of lab scale showed reproducible physical and chemical parameters. It could be concluded that a quality Pantoprazole oro-dispersible MUPS tablet was successfully designed using QbD approach to compression process variables.

Formulation and Evaluation of Oral Disintegrating Tablets of Lornoxicam by 3² Factorial Design.

Oral disintegrating dosage form provides an opportunity to manufacturers to extend product life cycle and to expand market. Oral disintegrating tablets (ODT) have this opportunity over conventional tablets. Lornoxicam is non steroidal anti-inflammatory drug and used in treatment of post traumatic pains, muscular and skeletal pains, joint disorder and rheumatic arthritis. Fast onset of action is required in these indications. Therefore it was thought to prepare ODT of Lornoxicam which would help to avoid first pass metabolism and to improve bioavailability as well. ODT were prepared by direct compression method by using crospovidone as superdisintegrating agent and optimized by 32 factorial design. Independent variables were concentration of crospovidone (X1) and hydroxypropyl cellulose (X2) while dependent variables were disintegration time and percent drug released. Optimised formulation, F4, showed drug content (97.90±0.37%), disintegration time (20.33±0.317 sec), percent drug released (101.5±0.59%), water absorption ratio (113.5±1.26%). This formulation was stable at 400C ±20C and RH 75%±5% for three months. Present study demonstrated potential for rapid absorption, improved bioavailability, effective therapy and patient compliance.

Phytosomal Drug Delivery Systems.

Certain of the water-soluble flavonoid molecules can be converted into lipid-compatible molecular complexes, aptly called phytosomes. Phytosomes are better able to transition from a hydrophilic environment into the lipid-friendly environment of the outer cell membrane, and from there into the cell, finally reaching the blood. The term "phyto" means plant while "some" means cell-like. Phytosome is a complex of a natural active ingredient and a phospholipid. It is claimed that phytosome increases absorption of "conventional herbal extracts" or isolated active principles. The phytosome process is that combines herbal extracts and soybean phospholipids (lecithin). phytosomes are created when the standardized extract and active ingredients of a herb are bound to the phospholipids on a molecular level. The newly created Phytosome structures contain the active ingredients of the herb surrounded by the phospholipids. The phospholipid molecular structure includes a water-soluble head and two fat-soluble tails. Because of this dual solubility, the phospholipid acts as an effective emulsifier. The newly created phytosome structures contain the active ingredients of the herb surrounded by the phospholipids. The phospholipid molecular structure includes a water-soluble head and two fat-soluble tails. Because of this dual solubility, the phospholipid acts as an effective emulsifier. An emulsifier is a material that can combine two liquids that normally will not mix well together. By combining the emulsifying action of the phospholipids with the standardized botanical extracts, the phytosome form provides dramatically enhanced bioavailability and delivers faster and improved absorption of the active constituents of the herb in the intestinal tract.

A Short Review on Aphrodisiac.

Aphrodisiacs can be categorized according to their mode of action into three groups: substances that increase libido (i.e., sexual desire, arousal), substances that increase sexual potency (i.e., effectiveness of erection) and substances that increase sexual pleasure. An aphrodisiac is a type of food or drink that has the effect of making those who eat or drink it more aroused in a sexual way. Some well-known aphrodisiacs are ginko, ashwaganda, oysters and chocolate. Ethnobotanical surveys have indicated a large number of plants as a aphrodisiac. This review summarizes the herbal plants with their experimental study, constituents and their potent aphrodisiac activity.